Myoepithelial Cells: Structure, Function and Role in Tumor Formation
نویسندگان
چکیده
Myoepithelial cells are smooth muscle like cells having epithelial origin. They are present in salivary glands, mammary gland, sweat gland and lacrimal gland. Myoepithelial cells are stellate or spindle shaped with 4 to 8 cytoplasmic processes. They play vital role during expulsion of saliva and regulates the electrolytic exchange. They also act as tumor suppressor and are considered very important role in differentiation of various salivary gland tumors and help in diagnosis of tumors.
منابع مشابه
Epithelial-Myoepithelial Carcinoma of the Palate: Report of a Case and Review of the Literatures
Epithelial-myoepithelial carcinoma (EMC) is considered as a rare malignant salivary gland neoplasm with good prognosis, low recurrence rate and rare metastasis. Here we present a case of epithelial-myoepithelial carcinoma in a 42-year-old female with a swelling of 3-year duration in her palate. Histopathologic evaluation of the lesion demonstrated a well-circumscribed, biphasic salivary gland t...
متن کاملبررسی توان القای مرگ سلولی سلولهای میو اپی تلیال موشی بر ردهی سلولی کارسینومای پستان
Background and Objective: Breast tumors include the heterogeneous population of various cells such as luminal and myoepithelial cells which can play a significant role in the development and/or the inhibition of breast cancer. It has been observed that paracrine and autocrine activities of myoepithelial cells can limit the mammary tumors via angiogenesis inhibition and apoptosis induction. Ther...
متن کاملA Case of Epithelial Myoepithelial Carcinoma – Correlation of IHC & Histopathological Findings
Epithelial myoepithelial carcinoma is a rare biphasic low grade neoplasm of salivary glands; it most commonly occurs in the parotid gland but can also arise in minor salivary glands. Here a case of 58-year-old female presented with left cheek swelling of one-year duration. CT scan revealed a localized submandibular salivary gland tumor mass not involving surrounding tissues. Histological examin...
متن کاملMaspin Gene Expression in Invasive Ductal Carcinoma of Breast
Background: The breast cancer is the most prevalent cancer among women, on the other hand absence of myoepithelial cells play a pivotal role in pathogenesis of this cancer. Thus we aimed to investigate the possible abilities of the molecular assay technique to find a relationship between mammary serine protease inhibitor (Maspin) gene expression possibly secreted by my...
متن کاملNormal and tumor-derived myoepithelial cells differ in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition.
The signals that determine the correct polarity of breast epithelial structures in vivo are not understood. We have shown previously that luminal epithelial cells can be polarized when cultured within a reconstituted basement membrane gel. We reasoned that such cues in vivo may be given by myoepithelial cells. Accordingly, we used an assay where luminal epithelial cells are incorrectly polarize...
متن کامل